In our Cancer Biology projects, we seek to understand how different types of cancer cells and immune cells control tumor survival, and what therapeutic strategies can be used to target various cancers. We are exploring the role of ferroptosis in several cancers, such as brain and liver cancers, examining the mechanism of drug resistance, and using single-cell methods to characterize the heterogeneity and the microenvironment in solid tumors.
We use diverse chemical and biological tools to elucidate new mechanisms related to cell death, metabolism, and disease. For example, we design small molecule inhibitors and activators of proteins using high resolution structural information and computational chemistry tools. We also create imaging probes to determine where different biomolecules are located in cells and tissues.