Active Research Projects
Cancer Biology
In our Cancer Biology projects, we seek to understand how different types of cancer cells and immune cells control tumor survival, and what therapeutic strategies can be used to target various cancers. We are exploring the role of ferroptosis in several cancers, such as brain and liver cancers, examining the mechanism of drug resistance, and using single-cell methods to characterize the heterogeneity and the microenvironment in solid tumors.
Chemical Biology
We use diverse chemical and biological tools to elucidate new mechanisms related to cell death, metabolism, and disease. For example, we design small molecule inhibitors and activators of proteins using high resolution structural information and computational chemistry tools. We also create imaging probes to determine where different biomolecules are located in cells and tissues.
Featured Publication
News
Dr. Hengrui Liu's GPX4 work featured on the cover of ACS Chemical Biology
ACS Chemical Biology features Stockwell Lab alumni Liu, et al. 2025 "Selective Small-Molecule Activator of Patient-Derived GPX4 Variant" on the cover of their latest print, highlighting chemical biology work performed in the Stockwell Lab.