Active Research Projects
Cancer Biology
In our Cancer Biology projects, we seek to understand how different types of cancer cells and immune cells control tumor survival, and what therapeutic strategies can be used to target various cancers. We are exploring the role of ferroptosis in several cancers, such as brain and liver cancers, examining the mechanism of drug resistance, and using single-cell methods to characterize the heterogeneity and the microenvironment in solid tumors.
Chemical Biology
We use diverse chemical and biological tools to elucidate new mechanisms related to cell death, metabolism, and disease. For example, we design small molecule inhibitors and activators of proteins using high resolution structural information and computational chemistry tools. We also create imaging probes to determine where different biomolecules are located in cells and tissues.
Recent Publication
MiR-940 Suppresses Ferroptosis by Controlling Expression of Key Regulatory Genes
News
ASBMB Today: The data that did not fit
Professor Stockwell was recently featured in an ASBMB Today Research Spotlight. Check it out here.
Columbia Magazine: "The Scientist Teaching Cancer to Self-Destruct"
“Ferroptosis,” a process discovered by Columbia biologist Brent R. Stockwell, could help defeat some of the deadliest cancers, including those of the brain, lung, and kidney.
Professor Stockwell named editor-in-chief of EXO - Beyond the Cell
Professor Stockwell has been named editor-in-chief of EXO - Beyond the Cell, a new spatial biology journal. Bringing together various leaders in the field, EXO is open-access and will serve as a hub for research exploring the ways cells interact with their environments. Learn more about the journal here and in Professor Stockwell's editorial.