We use diverse chemical and biological tools to elucidate new mechanisms related to cell death, metabolism, and disease. For example, we design small molecule inhibitors and activators of proteins using high resolution structural information and computational chemistry tools. We also create imaging probes to determine where different biomolecules are located in cells and tissues.
We often find using high resolution structural information on proteins helps design potent and selective ligands. We use computational chemistry tool, synthetic and medicinal chemistry, biochemistry, biophysics and structural biology to create such chemical probes and therapeutic candidates.
In addition, we create tagged biomolecules that can images by fluorescence, SRS or mass spectrometry in order to determine the cellular and sub cellular localization of such biomolecules, as shown in the image.
